Alergi kanggo Prilosec, Prevacid, Nexium, Aciphex lan Protonix
Proton Pump Inhibitors (PPIs) yaiku obat-obatan sing umum digunakake kanggo pengobatan penyakit refluks gastroesophageal (GERD) , panyakit ulkus peptik , lan uga kanggo perawatan infèksi. PPI nglakoni pamblokiran pompa asam ing weteng, saéngga ngurangi produksi asam, lan efektif banget kanggo nambani macem-macem penyakit gastrointestinal sing terkait asam.
Ana sawetara inhibitor pompa proton sing ana ing pasar, kalebu omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), rabeprazole (Aciphex) lan lansoprazole (Prevacid). Umumé, PPI obat sing aman banget karo sawetara efek samping. Iki bisa uga amarga alasan omeprazole lan lansoprazole disedhiyakake sacara over-the-counter / tanpa resep (kayata tanggal tulisan, esomeprazole, pantoprazole, lan rabeprazole mung kasedhiya kanthi resep).
Diagnosa Alergi kanggo Proton Pump Inhibitors
Reaksi alergi kanggo inhibitor pam proton ora umum nanging kedadeyan. Akeh reaksi kasebut kalebu urtikaria , asma, malah anafilaksis . Asring angel kanggo ngenali PPI minangka panyebab reaksi alergi kayata obat -obatan liyane, kalebu NSAIDs lan antibiotik kayata penisilin , asring diwenehi bebarengan karo PPI kanggo nyegah ulkus weteng utawa kanggo ngobati infeksi Helicobacter pylori .
Sawetara studi sing beda-beda wis ditindakake marang wong sing wis ngalami reaksi alergi minangka asil saka inhibitor pompa proton. Pengujian kulit , kayata cara prick lan intradermal, wis dilakoni kanthi nggunakake PPIs (lan obat liya sing ditindakake wong kasebut) sing bisa nyebabake reaksi alergi.
Tes kulit iki katon mbiyantu ngenali panyebab reaksi alergi, utamane nalika PPI dadi panyebab. Tantangan lisan sing nggunakake PPI sing nyebabake gejala reaksi alergi nalika tes kulit positif. Nanging, wong-wong sing tes kulit negatif ora tansah bisa ngidini PPI sing ditakonake sajrone tantangan lisan.
Reaktivitas Cross Antara Proton Pump Inhibitors
Ing lima protèin pompa proton beda ora mbagi struktur kimiawi sing padha, sing nuduhaké yèn wong sing alergi marang salah siji PPI, siji utawa luwih saka PPI liya bisa ditoleransi. Studi sing dilakoni ing interaktivitas salib ing inhibitor pompa proton wis nemokake yen wong alergi marang omeprazole asring alergi marang pantoprazole (lan kosok balene), lan wong sing alergi marang lansoprazole asring alergi marang rabeprazole (lan kosok balene). Reaktivitas salib iki amarga struktur sing padha antarane PPI tartamtu; Kurangi cross-reactivity antarane PPIs liyane bisa ngidini wong karo alergi menyang PPI tartamtu kanggo ngidini PPI liyane. Contone, wong alergi marang omeprazole utawa pantoprazole asring bisa njupuk lansoprazole utawa rabeprazole, lan sing alergi marang lansoprazole utawa rabeprazole asring bisa njupuk omeprazole utawa pantoprazole.
Kanggo wong-wong sing tau ngalami reaksi alergi minangka asil saka inhibitor pompa proton tartamtu, pengujian kulit uga bisa mbiyantu diagnosis. Yen penguji kulit PPI sing positif iku positif, pengujian kulit kanggo PPI non-salib-tindak-tindak bisa dileksanakake kanggo nemokake PPI sing bisa ngidini wong kasebut. Nanging, tantangan lisan, sing dilakoni ing pengawasan medis, kudu ditindakake kanthi PPI sing ora salaras (kanthi tes kulit negatif) kanggo mesthekake yen ditrima kanthi aman.
Sinau luwih lengkap babagan diagnosis lan perawatan alergi tamba .
> Sumber:
> Bonadonna P, et al. Hypersensitivity to Proton Pump Inhibitors: Diagnostic Accuracy of Tests Skin Compared to Test Provocation Oral. J Klinik Alergi Immunol. 2012; 130 (2): 547-9.
> Chang YS. Hypersensitivity Reaksi kanggo Proton Pump Inhibitors. Curr Opin Clinic Immunol. 2012; 12: 348-53.
> Lobera T, et al. Sembilan Kasus Omeprazole Alergi. Reaktivitas Cross Antara Proton Pump Inhibitors. J Investig Allergol Clin Immunol. 2009; 19: 57-60.
> Perez Pimiento AJ, et al. Hypersensitivity to Lansoprazole and Rabeprazole with Tolerance to Other Pump Inhibitors Proton. 2006; 117 (3): 707-8.